Unsaturated fatty acids lactose esters: cytotoxicity, permeability enhancement and antimicrobial activity

Lucarini, Simone and Fagioli, Laura and Campana, Raffaella and Cole, Hannah and Duranti, Andrea and Baffone, Wally and Vllasaliu, Driton and Casettari, Luca (2016) Unsaturated fatty acids lactose esters: cytotoxicity, permeability enhancement and antimicrobial activity. European Journal of Pharmaceutics and Biopharmaceutics, 107 . pp. 88-96. ISSN 0939-6411

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Item Type:Article
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Abstract

Sugar based surfactants conjugated with fatty acid chains are an emerging broad group of highly biocompatible and biodegradable compounds with established and potential future applications in the pharmaceutical, cosmetic and food industries. In this work, we investigated absorption enhancing and antimicrobial properties of disaccharide lactose, mono-esterified with unsaturated fatty acids through an enzymatic synthetic approach. After chemical and cytotoxicity characterizations, their permeability enhancing activity was demonstrated using intestinal Caco-2 monolayers through transepithelial electrical resistance (TEER) and permeability studies. The synthesised compounds, namely lactose palmitoleate (URB1076) and lactose nervonate (URB1077), were shown to exhibit antimicrobial activity versus eight pathogenic species belonging to Gram-positive, Gram-negative microorganisms and fungi.

Keywords:sugar-based surfactants, Permeability enhancers, NotOAChecked
Subjects:B Subjects allied to Medicine > B200 Pharmacology, Toxicology and Pharmacy
Divisions:College of Science > School of Pharmacy
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ID Code:23436
Deposited On:12 Jul 2016 14:44

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