The isolation and characterisation of the synthetic cannabinoid AM-2201 from commercial products using purification by HPLC-DAD

Duranovic, Smilja and Elie, Mathieu and Baron, Mark (2015) The isolation and characterisation of the synthetic cannabinoid AM-2201 from commercial products using purification by HPLC-DAD. Sample Preparation, 2 (1). pp. 74-81. ISSN 2299-677X

Full content URL: http://www.degruyter.com/view/j/sampre.2014.2.issu...

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Abstract

Abstract: A total of six products containing legal highs were purchased via the internet from the UK- based retailers and screened for the presence of synthetic cannabinoids using a fast GC-MS method and identified, in the absence of reference materials, by comparing the mass spectra with the Scientific Working Group for the Analysis of Seized Drugs (SWGDRUG) mass spectral library. Four synthetic cannabinoids were detected: RCS-4, CP-47, 497, UR-144 and AM-2201. The active ingredient (1-(5-fluoropentyl)-3-(1-naphthoyl) indole), with the street name AM-2201, detected in the product named Doob was isolated and purified from the methanolic extract of the product using preparative HPLC with analytical column (column overloading method). The structure of the substance was confirmed using NMR. This approach used common analytical equipment found in forensic and other analytical laboratories (except for the NMR), therefore can be useful for the identification of unknown psychoactive substances in drugs of abuse.

Keywords:AM-2201, fast GC-MS, preparative HPLC, JCOpen
Subjects:F Physical Sciences > F190 Chemistry not elsewhere classified
F Physical Sciences > F410 Forensic Science
F Physical Sciences > F100 Chemistry
F Physical Sciences > F180 Analytical Chemistry
Divisions:College of Science > School of Chemistry
ID Code:23072
Deposited On:28 Apr 2016 08:18

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