The interplay of variants near LEKR and CCNL1 and social stress in relation to birth size

Ali Khan, Anokhi and Rodriguez, Alina and Sebert, Sylvain and Kaakinen, Marika and Cauchi, Stéphane and Froguel, Philippe and Hartikainen, Anna-Liisa and Pouta, Anneli and Järvelin, Marjo-Riitta and UNSPECIFIED (2012) The interplay of variants near LEKR and CCNL1 and social stress in relation to birth size. PLoS ONE, 7 (6). e38216. ISSN 1932-6203

Full content URL: http://dx.doi.org/10.1371/journal.pone.0038216

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Abstract

Background

We previously identified via a genome wide association study variants near LEKR and CCNL1 and in the ADCY5 genes lead to lower birthweight. Here, we study the impact of these variants and social stress during pregnancy, defined as social adversity and neighborhood disparity, on infant birth size. We aimed to determine whether the addition of genetic variance magnified the observed associations.

Methodology/Principal Findings

We analyzed data from the Northern Finland Birth Cohort 1986 (n = 5369). Social adversity was defined by young maternal age (<20 years), low maternal education (<11 years), and/or single marital status. Neighborhood social disparity was assessed by discrepancy between neighborhoods relative to personal socio-economic status. These variables are indicative of social and socioeconomic stress, but also of biological risk. The adjusted multiple regression analysis showed smaller birth size in both infants of mothers who experienced social adversity (birthweight by −40.4 g, 95%CI −61.4, −19.5; birth length −0.14 cm, 95%CI −0.23, −0.05; head circumference −0.09 cm 95%CI −0.15, −0.02) and neighborhood disparity (birthweight −28.8 g, 95%CI −47.7, −10.0; birth length −0.12 cm, 95%CI −0.20, −0.05). The birthweight-lowering risk allele (SNP rs900400 near LEKR and CCNL1) magnified this association in an additive manner. However, likely due to sample size restriction, this association was not significant for the SNP rs9883204 in ADCY5. Birth size difference due to social stress was greater in the presence of birthweight-lowering alleles.

Conclusions/Significance

Social adversity, neighborhood disparity, and genetic variants have independent associations with infant birth size in the mutually adjusted analyses. If the newborn carried a risk allele rs900400 near LEKR/CCNL1, the impact of stress on birth size was stronger. These observations give support to the hypothesis that individuals with genetic or other biological risk are more vulnerable to environmental influences. Our study indicates the need for further research to understand the mechanisms by which genes impact individual vulnerability to environmental insults.

Keywords:Birth size
Subjects:C Biological Sciences > C800 Psychology
Divisions:College of Social Science > School of Psychology
ID Code:22929
Deposited On:27 Apr 2016 21:11

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