Maternal pre-pregnancy body mass index and offspring attention deficit hyperactivity disorder: a population-based cohort study using a sibling-comparison design

Chen, Qi and Sjolander, Arvid and Langstrom, Niklas and Rodriguez, Alina and Serlachius, Eva and D'Onofrio, Brian M. and Lichtenstein, Paul and Larsson, Henrik (2014) Maternal pre-pregnancy body mass index and offspring attention deficit hyperactivity disorder: a population-based cohort study using a sibling-comparison design. International Journal of Epidemiology, 43 (1). pp. 83-90. ISSN 0300-5771

Full content URL: http://dx.doi.org/10.1093/ije/dyt152

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Maternal pre-pregnancy body mass index and offspring attention deficit hyperactivity disorder: a population-based cohort study using a sibling-comparison design

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Abstract

Background High maternal pre-pregnancy body mass index (BMI) is associated with increased risk of offspring attention deficit hyperactivity disorder (ADHD). However, the role of unmeasured familial confounding for this association remains unclear.
Methods We conducted a population-based cohort study via linkage of Swedish national and regional registers to investigate maternal pre-pregnancy BMI (underweight: BMI <18.5; overweight: 25≤ BMI <30; obesity: BMI ≥30) in relation to offspring ADHD. We followed 673 632 individuals born in Sweden between 1992 and 2000, with prospectively collected information on maternal pre-pregnancy BMI, until they received an ADHD diagnosis or ADHD medication, death, emigration or 31 December 2009. Hazard ratios (HRs) were estimated by Cox proportional hazards models. Stratified Cox proportional hazards models were applied to data on full siblings to control for unmeasured familial confounding.
Results At the population level, pre-pregnancy overweight/obesity was associated with increased risk of offspring ADHD (HRoverweight = 1.23, 95% CI = 1.18–1.27, P = 0.01; HRobesity = 1.64, 95% CI = 1.57–1.73, P = 0.01), after adjustment for measured covariates. In full sibling comparisons, however, previously observed associations no longer remained (HRoverweight = 0.98, 95% CI = 0.83–1.16, P = 0.82; HRobesity = 1.15, 95% CI = 0.85–1.56, P = 0.38).
Conclusions The results suggested that the association between maternal pre-pregnancy overweight/obesity and offspring ADHD could be ascribed to unmeasured familial confounding.

Keywords:ADHD, attention deficit/hyperactivity disorder symptoms, maternal BMI, prenatal, confounding, sibling comparison, JCOpen
Subjects:C Biological Sciences > C820 Developmental Psychology
A Medicine and Dentistry > A990 Medicine and Dentistry not elsewhere classified
Divisions:College of Social Science > School of Psychology
ID Code:22926
Deposited On:27 Apr 2016 14:41

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