Genetics of Graves’ disease

Hamilton, Alexander and Gough, Stephen C. L. and Simmonds, Matthew J. (2013) Genetics of Graves’ disease. In: eLS - Encyclopedia of Life Sciences. Wiley. ISBN 9780470015902

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Abstract

Graves’ disease (GD) is a common autoimmune condition characterised by autoantibody attack against components of the thyroid gland which leads to hyperthyroidism. Both genetic and environmental factors have been implicated in disease onset. Uncovering the genetic contribution to GD has revealed that the disease is caused by a variety of factors encompassing both immunological and thyroid specific pathways. Recent advancements in genetic screening technologies, including the success of genome-wide association studies, have provided further insights into GD susceptibility loci. The challenge now is to determine how these newly found susceptibility loci play a role in disease while simultaneously identifying the remainder of the genetic contribution to GD. This will, in turn, piece together the complex pathogenic pathways associated with GD, painting a clearer picture of disease development and with it the provision of new opportunities for improved therapeutics and treatment strategies.

Keywords:Graves’ disease, Genome Wide Association Studies, Autoimmunity, Genetics, Susceptibility Loci, Human Leukocyte Antigen, Thyroid, Case control studies, Linkage disequilibrium, Autoimmune thyroid disease
Subjects:C Biological Sciences > C420 Human Genetics
Divisions:College of Science > School of Life Sciences
ID Code:22645
Deposited On:23 Mar 2016 16:20

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