Evaluation of five interleukin genes for association with end-stage renal disease in white Europeans

Buckham, T. A. and McKnight, A. J. and Benevente, D. and Courtney, A. E. and Patterson, C. C. and Simmonds, Matthew J. and Gough, S. C. L. and Middleton, D. and Borrows, R. and Maxwell, A. P. (2010) Evaluation of five interleukin genes for association with end-stage renal disease in white Europeans. American Journal of Nephrology, 32 (2). pp. 103-108. ISSN 0250-8095

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Abstract

Background: Genetic variation within interleukin genes has been reported to be associated with end-stage renal disease (ESRD). These findings have not been consistently replicated. No study has yet reported the comprehensive investigation of IL1A, IL1B, IL1RN, IL6 and IL10 genes. Methods: 664 kidney transplant recipients (cases) and 577 kidney donors (controls) were genotyped to establish if common variants in interleukin genes are associated with ESRD. Single nucleotide polymorphism (SNP) genotype data for each gene were downloaded for a northern and western European population from the International HapMap Project. Haploview was used to visualize linkage disequilibrium and select tag SNPs. Thirty SNPs were genotyped using MassARRAY ® iPLEX Gold technology and data were analyzed using the X2 test for trend. Independent replication was conducted in 1,269 individuals with similar phenotypic characteristics. Results: Investigating all common variants in IL1A, IL1B, IL1RN, IL6 and IL10 genes revealed a statistically significant association (rs452204 pempirical = 0.02) with one IL1RN variant and ESRD. This IL1RN SNP tags three other variants, none of which have previously been reported to be associated with renal disease. Independent replication in a separate transplant population of comparable size did not confirm the original observation. Conclusions: Common variants in these five candidate interleukin genes are not major risk factors for ESRD in white Europeans. Copyright © 2010 S. Karger AG, Basel.

Keywords:IL10 protein, human, IL1A protein, human, IL1B protein, human, IL1RN protein, human, IL6 protein, human, interleukin 1 receptor blocking agent, interleukin 10, interleukin 1alpha, interleukin 1beta, interleukin 6, interleukin derivative, adult, article, Caucasian, chronic kidney failure, ethnology, Europe, female, genetic predisposition, genetics, genotype, human, male, middle aged, single nucleotide polymorphism, Adult, European Continental Ancestry Group, Genetic Predisposition to Disease, Humans, Interleukin 1 Receptor Antagonist Protein, Interleukin-10, Interleukin-1alpha, Interleukin-1beta, Interleukin-6, Interleukins, Kidney Failure, Chronic, Polymorphism, Single Nucleotide
Subjects:C Biological Sciences > C431 Medical Genetics
Divisions:College of Science > School of Life Sciences
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ID Code:22608
Deposited On:01 Apr 2016 10:02

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