Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry

Hunt, K. A. and Smyth, D. J. and Balschun, T. and Ban, M. and Mistry, V. and Ahmed, T. and Barrett, J. C. and Bhaw-Rosun, L. and Bockett, N. A. and Brand, O. J. and Brouwer, E. and Concannon, P. and Cooper, J. D. and Dias, K-R. M. and van Diemen, C. C. and Dubois, P.C. and Edkins, S. and Fölster-Holst, R. and Fransen, K. and Glass, D. N. and Heap, G. A. R. and Hofmann, S. and Huizinga, T. W. J. and Hunt, S. and Langford, C. and Lee, J. and Mansfield, J. and Giovanna Marrosu, M. and Mathew, C. G. and Mein, C.A. and Müller-Quernheim, J. and Nutland, S. and Onengut-Gumuscu, S. and Ouwehand, W. and Pearce, K. and Prescott, N. and Posthumus, M. D. and Potter, S. and Rosati, G. and Sambrook, J. and Satsangi, J. and Schreiber, S. and Shtir, C. and Simmonds, M. J. and Sudman, M. and Thompson, S. D. and Toes, R. and Trynka, G. and Vyse, T. J. and Walker, N. M. and Weidinger, S. and Zhernakova, A. and Zoledziewska, M. and Weersma, R.K. and Gough, S.C.L. and Sawcer, S. and Wijmenga, C. and Parkes, M. and Cucca, F. and Franke, A. and Deloukas, P. and Rich, S. S. and Todd, J. A. and van Heel, D. A. (2011) Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry. Nature Genetics, 44 (1). pp. 3-5. ISSN 10614036

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Keywords:acetylesterase, sialic acid acetylesterase, unclassified drug, autoimmune disease, controlled study, enzyme activity, Europe, gene, gene frequency, genetic association, genetic predisposition, genetic risk, genetic variability, genotype, heritability, homozygote, human, letter, loss of function mutation, major clinical study, priority journal, SIAE gene, single nucleotide polymorphism, Acetylesterase, Autoimmune Diseases, European Continental Ancestry Group, Genetic Association Studies, Genetic Predisposition to Disease, Genetic Variation, Humans, Risk Factors
Subjects:C Biological Sciences > C420 Human Genetics
Divisions:College of Science > School of Life Sciences
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ID Code:22603
Deposited On:19 Mar 2016 22:48

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