Seven newly identified loci for autoimmune thyroid disease

Cooper, J. D. and Simmonds, M. J. and Walker, N.M. and Burren, O. and Brand, O.J. and Guo, H. and Wallace, C. and Stevens, H. and Coleman, G and Franklyn, J.A. and Todd, J.A. and Gough, S.C.L. (2012) Seven newly identified loci for autoimmune thyroid disease. Human Molecular Genetics, 21 (23). pp. 5202-5208. ISSN 0964-6906

Full content URL: http://dx.doi.org/10.1093/hmg/dds357

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Abstract

Autoimmune thyroid disease (AITD), including Graves' disease (GD) and Hashimoto's thyroiditis (HT), is one of the most common of the immune-mediated diseases. To further investigate the genetic determinants of AITD, we conducted an association study using a custom-made single-nucleotide polymorphism (SNP) array, the ImmunoChip. The SNP array contains all known and genotype-able SNPs across 186 distinct susceptibility loci associated with one or more immune-mediated diseases. After stringent quality control, we analysed 103 875 common SNPs (minor allele frequency >0.05) in 2285 GD and 462 HT patients and 9364 controls. We found evidence for seven new AITD risk loci (P < 1.12 � 10-6; a permutation test derived significance threshold), five at locations previously associated and two at locations awaiting confirmation, with other immune-mediated diseases. © The Author 2012. Published by Oxford University Press.

Keywords:article, autoimmune disease, controlled study, female, gene frequency, gene locus, genetic association, genetic susceptibility, genotype, Graves disease, Hashimoto disease, human, major clinical study, male, microarray analysis, priority journal, single nucleotide polymorphism, Autoimmune Diseases, Case-Control Studies, Chromosome Banding, Chromosome Mapping, Genetic Loci, Genetic Predisposition to Disease, Humans, Polymorphism, Single Nucleotide, Thyroid Diseases
Subjects:C Biological Sciences > C420 Human Genetics
Divisions:College of Science > School of Life Sciences
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ID Code:22601
Deposited On:11 Mar 2016 15:45

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