The differential effect of apoferritin-PbS nanocomposites on cell cycle progression in normal and cancerous cells

Turyanska, L. and Bradshaw, T. D. and Li, M. and Bardelang, P. and Drewe, W. C. and Fay, M. W. and Mann, S. and Patane, A. and Thomas, N. R. (2012) The differential effect of apoferritin-PbS nanocomposites on cell cycle progression in normal and cancerous cells. Journal of Materials Chemistry, 22 (2). pp. 660-665. ISSN 0959-9428

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Abstract

We report the effects induced by near-infrared apoferritin-PbS (AFt-PbS) nanocomposites on cell cycle progression in non-tumorigenic and cancerous human cells. By using flow cytometry and Annexin V assay, we show that the cell cycle of non-tumorigenic cells is not altered by exposure to AFt-PbS nanoparticles at concentrations up to 1 mg mL -1. In contrast, exposure of human-derived breast cancer cell lines to AFt-PbS at concentrations > 0.2 mg mL -1 triggers apoptotic cell death. The selective death of cancerous cells and the near-infrared fluorescence properties of AFt-PbS could be exploited in both nanomedicine and in vivo imaging studies. © 2012 The Royal Society of Chemistry.

Keywords:Annexins, Apoptotic cell death, Breast cancer cells, Cancerous cells, Cell cycle, Cell-cycle progression, Differential effect, Human cells, In-Vivo imaging, Near Infrared, Near-infrared fluorescence, Cell culture, Cell death, Flow cytometry, Infrared devices, Medical nanotechnology, Vanadium, Nanocomposites
Subjects:B Subjects allied to Medicine > B230 Pharmacy
F Physical Sciences > F100 Chemistry
Divisions:College of Science > School of Chemistry
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ID Code:22518
Deposited On:27 Mar 2016 15:09

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