An apoferritin-based drug delivery system for the tyrosine kinase inhibitor Gefitinib

Kuruppu, A. I. and Zhang, L. and Collins, H. and Turyanska, L. and Thomas, N. R. and Bradshaw, T. D. (2015) An apoferritin-based drug delivery system for the tyrosine kinase inhibitor Gefitinib. Advanced Healthcare Materials, 4 (18). pp. 2816-2821. ISSN 2192-2640

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Abstract

Anticancer drug Gefitinib encapsulated within human heavy chain apoferritin by diffusion allows pH-controlled sustained release of cargo. The combination of increased cellular uptake, and potent and enhanced antitumor activity against the HER2 overexpressing SKBR3 cell line compared to Gefitinib alone, makes it a promising carrier for delivery of drugs to tumor sites. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords:apoferritin, ferritin, gefitinib, iron, nanocomposite, protein tyrosine kinase inhibitor, antineoplastic activity, Article, biocompatibility, biodegradability, breast carcinoma, carcinoma cell line, cell pH, controlled study, drug delivery system, drug mechanism, drug release, drug structure, encapsulation, human, human cell, internalization, mass spectrometry, priority journal, protein function, protein structure, transmission electron microscopy, tumor microenvironment, NotOAChecked
Subjects:F Physical Sciences > F100 Chemistry
Divisions:College of Science > School of Chemistry
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ID Code:22508
Deposited On:07 Apr 2016 19:42

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