Metal free click chemistry on nucleosides and oligonucleotides

Singh, Ishwar and Heaney, Frances and Batchelor, Caroline and Vyle, Joseph S. (2015) Metal free click chemistry on nucleosides and oligonucleotides. Collection of Czechoslovak Chemical Communications, 10 . p. 451. ISSN 0010-0765

Documents
CCCC , ASAP Articles, css200810451 _ Collection of Czechoslovak Chemical Communications_metal free.pdf
[img]
[Download]
[img]
Preview
PDF
CCCC , ASAP Articles, css200810451 _ Collection of Czechoslovak Chemical Communications_metal free.pdf - Whole Document

139kB
Item Type:Article
Item Status:Live Archive

Abstract

Chemoselective ligation of biologically significant moieties through azide alkyne Click
Chemistry has recently received much attention1. The reaction is attractive in that it
regioselectively affords stable triazole linked bioconjugated products under mild conditions.
However, from the view point of the synthetic oligonucleotide chemist, a significant
disadvantage is that the non-thermal reaction requires an in situ generated Cu (I) catalyst.
Unwanted Cu (I) mediated chemistry, specifically oxidative degradation etc.

Keywords:Metal free click chemistry in water, DNA, NotOAChecked
Subjects:F Physical Sciences > F163 Bio-organic Chemistry
Divisions:College of Science > School of Pharmacy
Related URLs:
ID Code:22491
Deposited On:16 Mar 2016 14:36

Repository Staff Only: item control page