Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission

Nicoletti, F. and Battaglia, G. and Storto, M. and Ngomba, Richard T. and Iacovelli, L. and Arcella, A. and Gradini, R. and Sale, P. and Rampello, L. and De Vita, T. and Di Marco, R. and Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

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Abstract

Metabotropic glutamate (mGlu) receptors are G-protein coupled receptors activated by glutamate, the major excitatory neurotransmitter of the CNS. A growing body of evidence suggests that the function of mGlu receptors is not restricted to the regulation of synaptic transmission. mGlu receptors are expressed in a variety of peripheral cells, including inter alia hepatocytes, pancreatic cells, osteoblasts and immune cells. Within the immunological synapses, mGlu receptors expressed by T cells might contribute to the vast array of signals generated by the antigen-presenting cells. mGlu receptors are also found in embryonic and neural stem cells. This suggests their involvement in the pathophysiology of brain tumors, which likely originates from cancer stem cells similar to neural stem cells. Ligands of mGlu3 and mGlu4 receptors are potential candidates for the experimental treatment of malignant gliomas and medulloblastomas, respectively.

Keywords:G protein coupled receptor, glutamate receptor 1, glutamate receptor 3, glutamate receptor 4, metabotropic receptor, receptor subtype, antigen presenting cell, article, brain tumor, central nervous system, gene expression, glioblastoma, human, human cell, melanoma, neural stem cell, neurotransmission, pathophysiology, priority journal, receptor gene, stem cell, T lymphocyte, Animals, Glutamic Acid, Hepatocytes, Humans, Neoplastic Stem Cells, Osteoblasts, Pancreas, Receptors, Metabotropic Glutamate, Synaptic Transmission
Subjects:B Subjects allied to Medicine > B210 Pharmacology
B Subjects allied to Medicine > B140 Neuroscience
Divisions:College of Science > School of Pharmacy
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ID Code:22160
Deposited On:12 Feb 2016 12:22

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