The role of the melatoninergic system in epilepsy and comorbid psychiatric disorders

Tchekalarova, Jana and Moyanova, Slavianka and Fusco, Antonio De and Ngomba, Richard Teke (2015) The role of the melatoninergic system in epilepsy and comorbid psychiatric disorders. Brain Research Bulletin, 119 (A). pp. 80-92. ISSN 0361-9230

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Abstract

Abstract

There is emerging evidence of the beneficial role of the melatonin system in a wide range of psychiatric and neurologic disorders, including anxiety, depression, and epilepsy. Although melatoninergic drugs have chronobiotic and antioxidant properties that positively influence circadian rhythm desynchronization and neuroprotection in neurodegenerative disorders, studies examining the use of melatonin for epilepsy's comorbid psychiatric and neurological symptomatology are still limited. Preclinical and clinical findings on the beneficial effects of the melatonin system on anxiety, depression, and epilepsy suggest that melatoninergic compounds might be effective in treating comorbid behavioral complications in epilepsy beyond regulation of a disturbed sleep-wake cycle.

Keywords:Anxiety; Chronopharmacology; Depression; Epilepsy; Melatonin, NotOAChecked
Subjects:A Medicine and Dentistry > A100 Pre-clinical Medicine
Divisions:College of Science > School of Pharmacy
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ID Code:20035
Deposited On:17 Jan 2016 20:43

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