The modulation of class II histocompatibility antigens and 'activated' macrophage determinant in the spinal cord during the development of chronic relapsing experimental allergic encephalomyelitis (CREAE) in the guinea pig-relevance to the induction of remission?

Antoniou, A. V. and El-Sady, H. and Butter, C. and Turk, J. L. (1987) The modulation of class II histocompatibility antigens and 'activated' macrophage determinant in the spinal cord during the development of chronic relapsing experimental allergic encephalomyelitis (CREAE) in the guinea pig-relevance to the induction of remission? Journal of Neuroimmunology, 15 (1). pp. 57-71. ISSN 0165-5728

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Item Type:Article
Item Status:Live Archive

Abstract

Cryostat sections of spinal cord of guinea pigs with chronic relapsing experimental allergic encephalomyelitis (CREAE) were stained with monoclonal antibodies recognising a Strain 13-specific Ia epitope, a non-strain-specific Ia antigen and an 'activated' macrophage determinant. It was found that both Ia antigens and the 'activated' macrophage determinant, observed on infiltrating cells within both perivascular and menigeal compartments, appeared to be modulated during the course of CREAE. This correlated with the neurological symptoms of the disease. Blood vessels and 'glial' cells expressed both Ia determinants. 'Glial' cells also expressed the 'activated' macrophage antigen. These antigens were modulated with the course of the disease. © 1987.

Keywords:Ia antigen, monoclonal antibody, allergic encephalomyelitis, central nervous system, cytology, guinea pig, heredity, immunohistochemistry, macrophage, nonhuman, priority journal, spinal cord, Animal, Antibodies, Monoclonal, Encephalomyelitis, Experimental Autoimmune, Guinea Pigs, Histocompatibility Antigens Class II, HLA-D Antigens, Immunoenzyme Techniques, Macrophage Activation, Macrophages, Remission Induction, Spinal Cord, Support, Non-U.S. Gov't
Subjects:B Subjects allied to Medicine > B100 Anatomy, Physiology and Pathology
C Biological Sciences > C741 Medical Biochemistry
Divisions:College of Science > School of Life Sciences
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ID Code:19878
Deposited On:28 Dec 2015 22:45

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