An immunoelectron microscopical study of the expression of class II MHC and a T lymphocyte surface marker during chronic relapsing experimental allergic encephalomyelitis

Butter, C. and Healey, D. G. and Agha, Naveeda and Turk, I. L. (1988) An immunoelectron microscopical study of the expression of class II MHC and a T lymphocyte surface marker during chronic relapsing experimental allergic encephalomyelitis. Journal of Neuroimmunology, 20 (1). pp. 45-51. ISSN 0165-5728

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Abstract

Immunoelectron microscopy using antibodies recognising Class II MHC antigens and a pan T cell marker was employed to study sections of spinal cord from guinea pigs with chronic relapsing experimental allergic encephalomyelitis (CREAE). It was found that endothelial cells expressed Class II antigens on their luminal surface throughout the course of the disease and that lymphocytes were adherent to these surfaces. In the parenchyma lymphocytes, macrophages and possibly microglia expressed Class II antigens suggesting that they might also be involved in antigen presentation. The different distribution of T cells seen in the individual lesions during the relapse phase may correlate with their respective natural histories. © 1988.

Keywords:HLA antigen, allergic encephalomyelitis, animal cell, animal experiment, guinea pig, nonhuman, priority journal, t lymphocyte, ultrastructure, Animal, Antigens, Surface, Chronic Disease, Encephalomyelitis, Experimental Autoimmune, Fixatives, Freund's Adjuvant, Guinea Pigs, Histological Techniques, HLA-DR Antigens, Immunologic Techniques, Microscopy, Electron, Reference Values, Support, Non-U.S. Gov't, T-Lymphocytes
Subjects:B Subjects allied to Medicine > B100 Anatomy, Physiology and Pathology
C Biological Sciences > C741 Medical Biochemistry
Divisions:College of Science > School of Life Sciences
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ID Code:19877
Deposited On:28 Dec 2015 22:46

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