The localisation of fibrin, fibronectin and class II major histocompatibility complex antigen in the spinal cord in chronic relapsing experimental allergic encephalomyelitis

Butter, C. and Healey, Naveeda Agha, Caroline E., D. G. and Agha, Naveeda and Wilcox, Caroline E. and Turk, J. L. (1989) The localisation of fibrin, fibronectin and class II major histocompatibility complex antigen in the spinal cord in chronic relapsing experimental allergic encephalomyelitis. Journal of Neuroimmunology, 22 (1). pp. 11-17. ISSN 0165-5728

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Item Type:Article
Item Status:Live Archive

Abstract

Light and electron immunocytochemistry using antibodies recognising a class II major histocompatibility complex antigen, fibrin, fibronectin, albumin and factor VIII related antigen has been used to stain sections of spinal cord from normal guinea pigs and those with chronic relapsing experimental allergic encephalomyelitis (CREAE). It was found that class II MHC antigens, fibronin and fibronectin were present in normal blood vessels and at high levels in lesions from animal at all stages of the disease. The possible immunological roles of these antigens suggest their participation in the initiation and maintenace of disease state. © 1989.

Keywords:fibrin, fibronectin, major histocompatibility antigen class 2, monoclonal antibody, allergic encephalomyelitis, animal experiment, endothelium cell, enzyme linked immunosorbent assay, female, guinea pig, histochemistry, histology, immunocytochemistry, male, nonhuman, priority journal, spinal cord, ultrastructure, Animal, Antibodies, Monoclonal, Blood Vessels, Chronic Disease, Encephalomyelitis, Experimental Autoimmune, Fibronectins, Guinea Pigs, Histocompatibility Antigens Class II, Immunologic Techniques, Microscopy, Electron, Recurrence, Staining and Labeling, Support, Non-U.S. Gov't
Subjects:B Subjects allied to Medicine > B100 Anatomy, Physiology and Pathology
C Biological Sciences > C700 Molecular Biology, Biophysics and Biochemistry
Divisions:College of Science > School of Life Sciences
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ID Code:19875
Deposited On:28 Dec 2015 23:13

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