An immunoelectronmicroscopical study of the expression of major histocompatibility complex (MHC) class II antigens in guinea pig sciatic nerves following induction of intraneural mycobacterial granulomas

Cowley S.A., S. A. and Butter, C. and Gschmeissner, S. E. and Curtis, J. and Turk, J. L. (1989) An immunoelectronmicroscopical study of the expression of major histocompatibility complex (MHC) class II antigens in guinea pig sciatic nerves following induction of intraneural mycobacterial granulomas. Journal of Neuroimmunology, 23 (3). pp. 223-231. ISSN 0165-5728

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Item Type:Article
Item Status:Live Archive

Abstract

A guinea pig model of nerve damage in leprosy has been used to investigate the expression of major histocompatibility complex (MHC) class II antigens in granulomatous lesions in nerves. Using an immunoelectronmicroscopical technique, infiltrating mononuclear cells and endoneural fibroblast-like cells are shown to be class II-positive in the experimental neural lesions. Schwann cells are not class II-positive under these conditions, although at the light microscope level Schwann cell-like cells appear to be positively stained. This illustrates the value of immunoelectronmicroscopy in the investigation of cell surface proteins in situ as compared with conventional light immunohistochemistry. © 1989.

Keywords:major histocompatibility antigen class 2, animal experiment, granuloma, histochemistry, mycobacterium, nonhuman, peripheral nerve, priority journal, ultrastructure, Animal, Female, Guinea Pigs, Histocompatibility Antigens Class II, Immunohistochemistry, Microscopy, Electron, Mycobacterium Infections, Nervous System Diseases, Sciatic Nerve, Support, Non-U.S. Gov't
Subjects:B Subjects allied to Medicine > B100 Anatomy, Physiology and Pathology
C Biological Sciences > C700 Molecular Biology, Biophysics and Biochemistry
Divisions:College of Science > School of Life Sciences
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ID Code:19874
Deposited On:29 Dec 2015 18:34

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