A quantitative immunocytochemical study of the infiltrating lymphocytes in the spinal cord of guinea pigs with chronic relapsing experimental allergic encephalomyelitis

Butter, C. and Healey, D. G. and Baker, D. and Turk, J. L. (1989) A quantitative immunocytochemical study of the infiltrating lymphocytes in the spinal cord of guinea pigs with chronic relapsing experimental allergic encephalomyelitis. Journal of Neuroimmunology, 25 (2-3). pp. 169-176. ISSN 0165-5728

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Item Type:Article
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Abstract

The production and characterization of an anti-guinea pig B cell monoclonal antibody is described. Immunocytochemical techniques using this antibody and others recognizing a Pan T cell antigen and T cell subsets were employed to study frozen sections of spinal cord from guinea pigs with chronic relapsing experimental allergic encephalomyelitis. T and B cells were found in both perivascular lesions and the central nervous system parenchyma, with the major T cell infiltration occuring by the end of the acute phase of disease. The distribution of T cell subsets suggests a phenotypic selectivity in favour of the transport of CT6 (putative CD8)+ve cells across the blood-brain barrier. © 1989.

Keywords:allergic encephalomyelitis, animal experiment, b lymphocyte, cell infiltration, cytochemistry, guinea pig, lymphocyte, mammal, nonhuman, priority journal, spinal cord, t lymphocyte, Animal, Antibodies, Monoclonal, B-Lymphocytes, Blood Vessels, Chronic Disease, Encephalomyelitis, Experimental Autoimmune, Guinea Pigs, Immunohistochemistry, Lymphocytes, Recurrence, Support, Non-U.S. Gov't, T-Lymphocytes
Subjects:B Subjects allied to Medicine > B100 Anatomy, Physiology and Pathology
C Biological Sciences > C700 Molecular Biology, Biophysics and Biochemistry
Divisions:College of Science > School of Life Sciences
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ID Code:19873
Deposited On:28 Dec 2015 23:04

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