Induction of chronic relapsing experimental allergic encephalomyelitis in Biozzi mice

Baker, D. and O'Neil, J. K. and Gschmeissner, S. E. and Wilcox, C. E. and Butter, C. and Turk, J. L. (1990) Induction of chronic relapsing experimental allergic encephalomyelitis in Biozzi mice. Journal of Neuroimmunology, 28 (3). pp. 261-270. ISSN 0165-5728

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Item Type:Article
Item Status:Live Archive

Abstract

Experimental allergic encephalomyelitis (EAE) was induced in Biozzi AB/H (antibody high) mice by sensitization with spinal cord homogenate in adjuvant. Biozzi AB/H mice were highly susceptible to EAE induction and followed a chronic relapsing pattern of disease. Disease episodes were characterized by mononuclear infiltration of the central nervous system, with demyelination being particularly evident in relapse. The cellular infiltrates, which were associated with immunoglobulin deposition, consisted of macrophages and primarily CD4-positive T lymphocytes. However, similarly treated Biozzi AB/L (antibody low) mice were markedly less susceptible to EAE induction than AB/H mice. Thus, Biozzi mice should prove valuable for the study of chronic relapsing EAE. © 1990.

Keywords:antibody, aged, allergic encephalomyelitis, animal cell, article, female, histochemistry, male, mouse, nonhuman, priority journal, t lymphocyte, ultrastructure, Animal, Antibody Formation, Chronic Disease, Encephalomyelitis, Experimental Autoimmune, Histocompatibility Antigens Class II, Mice, Spinal Cord, Support, Non-U.S. Gov't, T-Lymphocytes
Subjects:C Biological Sciences > C700 Molecular Biology, Biophysics and Biochemistry
Divisions:College of Science > School of Life Sciences
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ID Code:19871
Deposited On:31 Dec 2015 21:16

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