An immunoelectron microscopical study of the expression of class II major histocompatibility complex during chronic relapsing experimental allergic encephalomyelitis in Biozzi AB/H mice

Butter, C. and O'Neill, J. K. and Baker, D. and Gschmeissner, S. E. and Turk, J. L. (1991) An immunoelectron microscopical study of the expression of class II major histocompatibility complex during chronic relapsing experimental allergic encephalomyelitis in Biozzi AB/H mice. Journal of Neuroimmunology, 33 (1). pp. 37-42. ISSN 0165-5728

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Item Type:Article
Item Status:Live Archive

Abstract

Immunoelectron microscopical techniques have been used to study class II major histocompatibility complex (MHC) expression by cells in the spinal cords of Biozzi AB/H mice with chronic relapsing experimental allergic encephalomyelitis. Throughout the course of disease both astrocytes and endothelia failed to express significant levels of class II MHC antigens. The major central nervous system resident cell types found to express class II MHC antigens were the perivascular microglia, with infiltrating macrophages and some lymphocytes being strongly positive. © 1991.

Keywords:HLA antigen, aged, allergic encephalomyelitis, animal tissue, article, astrocyte, cell culture, controlled study, mouse, multiple sclerosis, nonhuman, priority journal, spinal cord, ultrastructure, Animal, Chronic Disease, Encephalomyelitis, Experimental Autoimmune, Histocompatibility Antigens Class II, Immunohistochemistry, Mice, Microscopy, Immunoelectron, Recurrence, Support, Non-U.S. Gov't
Subjects:B Subjects allied to Medicine > B100 Anatomy, Physiology and Pathology
C Biological Sciences > C700 Molecular Biology, Biophysics and Biochemistry
Divisions:College of Science > School of Life Sciences
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ID Code:19870
Deposited On:28 Dec 2015 23:18

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