The BAFF-Interacting receptors of chickens

Reddy, Shalina K. and Hu, Tuanjun and Gudivada, Rao and Staines, Karen and Wright, Kathryn E. and Vickerstaff, Lucy and Kothlow, Sonja and Hunt, Lawrence G. and Butter, Colin and Kaspers, Bernd and Young, John R. (2008) The BAFF-Interacting receptors of chickens. Developmental and Comparative Immunology, 32 (9). pp. 1076-1087. ISSN 0145-305X

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Item Type:Article
Item Status:Live Archive

Abstract

The TNF superfamily cytokine BAFF has crucial roles in homoeostatic regulation of B cell populations in mammals. Similar effects on peripheral B cells have been reported for chicken as for mammalian BAFF. Unlike mammalian BAFF, chicken BAFF is produced by B cells, implying an autocrine loop and consequent differences in regulation of B cell homoeostasis. Understanding of these mechanisms requires investigation of BAFF-binding receptors in chickens. We identified and characterised chicken receptors BAFFR and TACI, but found that the gene encoding the third BAFF-binding receptor, BCMA, was disrupted, implying differences in mechanisms for maintenance of long-lived antibody responses. A BAFFR-Ig fusion protein expressed in vivo lowered B cell numbers, showing that it was functional under physiological conditions. We found changes in the ratio of BAFFR and TACI mRNAs in the bursa after hatch that may account for the altered requirements for B cell survival at this stage of development. © 2008 Elsevier Ltd. All rights reserved.

Keywords:B cell activating factor, B cell activating factor receptor, B cell maturation antigen, immunoglobulin, messenger RNA, transmembrane activator and CAML interactor, animal cell, animal tissue, antibody response, article, autocrine effect, B lymphocyte, cell survival, chicken, controlled study, hatching, homeostasis, lymphocyte count, lymphocyte function, nonhuman, nucleotide sequence, priority journal, protein binding, protein expression, regulatory mechanism, Amino Acid Sequence, Animals, B-Cell Activation Factor Receptor, B-Lymphocytes, Bursa of Fabricius, Cell Line, Chick Embryo, Chickens, Humans, Mice, Molecular Sequence Data, Recombinant Fusion Proteins, Sequence Alignment, Transmembrane Activator and CAML Interactor Protein, Gallus gallus, Mammalia
Subjects:D Veterinary Sciences, Agriculture and related subjects > D300 Animal Science
Divisions:College of Science > School of Life Sciences
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ID Code:19862
Deposited On:01 Jan 2016 19:25

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