APOE ɛ2 is associated with white matter hyperintensity volume in CADASIL

Gesierich, Benno and Opherk, Christian and Rosand, Jonathan and Gonik, Mariya and Malik, Rainer and Jouvent, Eric and Hervé, Dominique and Adib-Samii, Poneh and Bevan, Steve and Pianese, Luigi and Silvestri, Serena and Dotti, Maria T. and De Stefano, Nicola and van der Grond, Jeroen and Boon, Elles M. J. and Pescini, Francesca and Rost, Natalia and Pantoni, Leonardo and Lesnik Oberstein, Saskia A. and Federico, Antonio and Ragno, Michele and Markus, Hugh S. and Tournier-Lasserve, Elisabeth and Chabriat, Hugues and Dichgans, Martin and Duering, Marco and Ewers, Michael (2016) APOE ɛ2 is associated with white matter hyperintensity volume in CADASIL. Journal of Cerebral Blood Flow & Metabolism . ISSN 0271-678X

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Item Type:Article
Item Status:Live Archive

Abstract

Apolipoprotein E (APOE) increases the risk for Alzheimer’s disease (ε4 allele) and cerebral amyloid angiopathy (ε2 and ε4), but its role in small vessel disease (SVD) is debated. Here we studied the effects of APOE on white matter hyperintensity volume (WMHV) in CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy), a nonamyloidogenic angiopathy and inherited early-onset form of pure SVD. Four hundred and eighty-eight subjects were recruited through a multicenter consortium. Compared with APOE ε3/ε3, WMHV was increased in APOE ε2 (P=0.02) but not APOE ε4. The results remained significant when controlled for genome-wide genetic background variation. Our findings suggest a modifying influence of APOE ε2 on WMHV caused by pure SVD.

Keywords:Genetics, NotOAChecked
Subjects:C Biological Sciences > C431 Medical Genetics
Divisions:College of Science > School of Life Sciences
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ID Code:19447
Deposited On:22 Nov 2015 20:07

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