Inflammatory islet damage in patients bearing HLA-DR 3 and/or DR 4 haplotypes does not lead to islet autoimmunity

Lampeter, E. F. and Kolb, H. and Seifert, I. and Lohmann, D. and Heise, J. W. and Bertrams, J. and Christie, Michael and Kolb-Bachofen, V. (1994) Inflammatory islet damage in patients bearing HLA-DR 3 and/or DR 4 haplotypes does not lead to islet autoimmunity. Diabetologia, 37 (5). pp. 471-475. ISSN 0012-186X

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Item Type:Article
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Abstract

The hypothesis was tested that islet autoimmunity is induced by ongoing islet cell destruction in subjects with susceptibility genes HLA-DR 3 and/or DR 4. Sixty-one patients with confirmed chronic pancreatitis were analysed, 30 of whom expressed HLA-DR 3 and/or DR 4. Electron microscopy studies in 10 patients showed that the inflammatory process also affected islets, as recognisable from islet cell lysis, intrainsular fibrosis and immune cell infiltrates. None of the sera tested contained any of three markers of islet autoimmunity, ICA, IAA or GAD antibodies. A correlation was seen between the loss of exocrine function, as determined by the ALTAB-test, and of beta-cell function, as determined by the C-peptide response to i.v. glucagon. However, there was no preferential loss of beta-cell function in patients with HLA-DR 3 and/or DR 4. We conclude that islet cell destruction occurs during chronic pancreatitis, but does not trigger islet autoimmunity, even in the presence of HLA-DR 3 and/or DR 4. © 1994 Springer-Verlag.

Keywords:HLA DR3 antigen, HLA DR4 antigen, adult, aged, article, autoimmunity, controlled study, female, human, inflammation, insulin dependent diabetes mellitus, major clinical study, male, pancreatitis, priority journal, Adult, Autoantibodies, Biological Markers, Chronic Disease, Disease Susceptibility, Haplotypes, HLA-DR3 Antigen, HLA-DR4 Antigen, Humans, Insulin, Insulin Antibodies, Islets of Langerhans, Middle Aged
Subjects:A Medicine and Dentistry > A100 Pre-clinical Medicine
Divisions:College of Science > School of Life Sciences
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ID Code:18159
Deposited On:31 Jul 2015 10:49

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