Asymmetric aldol reaction of α,α-disubstituted acetaldehydes catalyzed by Ddphenylprolinol silyl ether for the construction of quaternary stereogenic centers

Hayashi, Yujiro and Shomura, Hiroki and Xu, Qianqian and Lear, Martin and Sato, Itaru (2015) Asymmetric aldol reaction of α,α-disubstituted acetaldehydes catalyzed by Ddphenylprolinol silyl ether for the construction of quaternary stereogenic centers. European Journal of Organic Chemistry, 20 . pp. 4316-4319. ISSN 1434-193X

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Abstract

The asymmetric cross-aldol reaction of α,α-disubstituted acetaldehydes with commercial ethyl glyoxylate polymer was successfully catalyzed by diphenylprolinol silyl ether 3 to generate all-carbon quaternary stereogenic centers with good enantioselectivity.

Keywords:Organocatalysis, Asymmetric synthesis, bmjgoldcheck, NotOAChecked
Subjects:F Physical Sciences > F160 Organic Chemistry
F Physical Sciences > F100 Chemistry
Divisions:College of Science > School of Chemistry
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ID Code:17520
Deposited On:07 Jun 2015 17:27

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