Design, preparation and assessment of surface-immobilised tetraphenylethenes for biosensing applications

Brennecke, Johannes and Ochs, Christopher J. and Boudhar, Aïcha and Reux, Bastien and Subramanian, Gomathy Sandhya and Lear, Martin J. and Trau, Dieter and Hobley, Jonathan (2014) Design, preparation and assessment of surface-immobilised tetraphenylethenes for biosensing applications. Applied Surface Science, 307 . pp. 475-481. ISSN 0169-4332

Full content URL: http://dx.doi.org/10.1016/j.apsusc.2014.04.061

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Abstract

Tetraphenylethene (TPE) shows a significant increase of fluorescence intensity when the rotational free-dom of its phenyl groups is restricted. This special property allows the use of TPE in sensor applications,which have been previously described for the liquid phase only. However, some applications utilisingarrays require the immobilisation of TPE dyes on solid surfaces. In this work, we synthesised and investi-gated the fluorescence behaviour of TPE derivatives on silica particles and quartz slides and suggest waysto employ the dye’s properties in solid phase biosensor applications.

Keywords:tetraphenylethene, bioassay, fluorescent dye, microparticles, reagentless assay, NotOAChecked
Subjects:F Physical Sciences > F200 Materials Science
F Physical Sciences > F170 Physical Chemistry
F Physical Sciences > F160 Organic Chemistry
Divisions:College of Science > School of Chemistry
ID Code:17129
Deposited On:23 Apr 2015 13:18

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