Laetirobin from the parasitic growth of Laetiporus sulphurous on Robinia pseudoacacia

Lear, Martin J. and Simon, Oliver and Foley, Timothy L. and Burkart, Michael D. and Baiga, Thomas J. and Noel, Joseph P. and DiPasquale, Antonio G. and Rheingold, Arnold L. and La Clair, James J. (2009) Laetirobin from the parasitic growth of Laetiporus sulphurous on Robinia pseudoacacia. Journal of Natural Products, 72 (11). pp. 1980-1987. ISSN 0163-3864

Full content URL: http://dx.doi.org/10.1021/np9002838

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Laetirobin from the parasitic growth of Laetiporus sulphurous on Robinia pseudoacacia

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Abstract

Laetirobin (1) was isolated as a cytostatic lead from Laetiporus sulphureus growing parasitically on the black locust tree, Robinia pseudoacacia, by virtue of a reverse-immunoaffinity system. Using an LC/MS procedure, milligram quantities of laetirobin (1) were obtained, and the structure of 1 was elucidated by X-ray crystallography and confirmed by NMR spectroscopy. Preliminary cellular studies indicated that laetirobin (1) rapidly enters in tumor cells, blocks cell division at a late stage of mitosis, and invokes apoptosis.

Keywords:Lead discovery, Natural products, Chemical characterisation, Immuno-affinity screening
Subjects:F Physical Sciences > F165 Biomolecular Chemistry
F Physical Sciences > F160 Organic Chemistry
F Physical Sciences > F163 Bio-organic Chemistry
Divisions:College of Science > School of Chemistry
ID Code:17116
Deposited On:17 Apr 2015 10:33

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