Total synthesis of a fully lipidated form of phosphatidyl-myo-inositol dimannoside (PIM-2) of Mycobacterium tuberculosis

Ali, Asif and Wenk, Markus R. and Lear, Martin J. (2009) Total synthesis of a fully lipidated form of phosphatidyl-myo-inositol dimannoside (PIM-2) of Mycobacterium tuberculosis. Tetrahedron Letters, 50 (40). pp. 5664-5666. ISSN 0040-4039

Full content URL: http://dx.doi.org/10.1016/j.tetlet.2009.07.109

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Abstract

Using an orthogonal protecting group approach to resolve racemic myo-inositol directly as its D-mannoside, we report a [2+n]-glycan/phosphatidylation strategy to assemble a bis-palmityl, tuberculostearyl form of phosphatidyl-myo-inositol dimannoside (PIM-2).

Keywords:Total synthesis, Glycolipids, Asymmetric resolution
Subjects:F Physical Sciences > F160 Organic Chemistry
Divisions:College of Science > School of Chemistry
ID Code:17113
Deposited On:16 Apr 2015 13:14

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