An oxidatively coupled dimer of paracetamol

Clegg, W. and Teat, S. J. and Prasad, K. V. R. and Ristic, R. I. and Sheen, D. B. and Shepherd, E. A. and Sherwood, J. N. and Vrcelj, R. M. (1998) An oxidatively coupled dimer of paracetamol. Acta Crystallographica Section C Crystal Structure Communications, 54 (12). pp. 1881-1882. ISSN 0108-2701

Documents
fg1496[1].pdf
[img]
[Download]
[img]
Preview
PDF
fg1496[1].pdf - Whole Document

214kB
Item Type:Article
Item Status:Live Archive

Abstract

The title compound, 5,5'-bis (acetylamino)-2, 2'-dihydroxybiphenyl,
is a minor oxidation product formed
from paracetamol. Its monohydrate, CI6HI6N204.H20,
has an extensively hydrogen-bonded crystal structure involving
N--H...O(hydroxy), (hydroxy)O---H...O(water)
and (water)O--H...O(carbonyl) interactions in a threedimensional
network, with both the oxidation product
and the water molecule lying on a twofold axis. The
two halves of the molecule have essentially the same
geometry as paracetamol in its two known anhydrous
polymorphs, except for the variation observed in the
dihedral angle between the aromatic ring and its amide
substituent.

Keywords:Crystallography, Paracetamol
Subjects:F Physical Sciences > F131 Crystallography
Divisions:College of Science > School of Pharmacy
Related URLs:
ID Code:16744
Deposited On:18 Feb 2015 12:27

Repository Staff Only: item control page