Enforcing Ostwald's rule of stages: isolation of paracetamol forms III and II

Burley, Jonathan C. and Duer, Melinda J. and Stein, Robin S. and Vrcelj, Ranko M. (2007) Enforcing Ostwald's rule of stages: isolation of paracetamol forms III and II. European Journal of Pharmaceutical Sciences, 31 (5). pp. 271-276. ISSN 0928-0987

Full content URL: http://dx.doi.org/10.1016/j.ejps.2007.04.002

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Enforcing Ostwald's rule of stages: isolation of paracetamol forms III and II

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Abstract

We have been able to isolate and study the polymorphic form III of paracetamol using a specially
designed methodology. Our work represents the first report of a reproducible, reliable
route to form III. This has been an outstanding problem for over quarter of a century. Our
method may be applicable to the isolation of metastable polymorphs of other compounds.

Keywords:polymorphism, paracetamol
Subjects:F Physical Sciences > F130 Structural Chemistry
F Physical Sciences > F151 Pharmaceutical Chemistry
Divisions:College of Science > School of Pharmacy
ID Code:16733
Deposited On:18 Feb 2015 16:22

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