Production of reference materials for the detection and size determination of silica nanoparticles in tomato soup

Grombe, Ringo and Charoud-Got, Jean and Emteborg, Haken and Linsinger, Thomas P. J. and Seghers, John and Wagner, Stephan and von der Kammer, Frank and Hofmann, Thilo and Dudkiewicz, Agnieszka and Llinas, Meritxell and Solans, Conxita and Lehner, Angela and Allmaier, Gunter (2014) Production of reference materials for the detection and size determination of silica nanoparticles in tomato soup. Analytical and Bioanalytical Chemistry, 406 (16). pp. 3895-3907. ISSN 1618-2642

Full content URL: http://link.springer.com/article/10.1007%2Fs00216-...

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Production of reference materials for the detection and size determination of silica nanoparticles in tomato soup

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Abstract

A set of four reference materials for the detection and quantification of silica nanoparticles (NPs) in food was produced as a proof of principle exercise. Neat silica suspensions were ampouled, tested for homogeneity and stability, and characterized for total silica content as well as particle diameter by dynamic light scattering (DLS), electron microscopy (EM), gas-phase electrophoretic molecular mobility analysis (GEMMA), and field-flow fractionation coupled with an inductively coupled mass spectrometer (FFF-ICPMS). Tomato soup was prepared from ingredients free of engineered nanoparticles and was spiked at two concentration levels with the silica NP suspension. Homogeneity of these materials was found sufficient to act as reference materials and the materials are sufficiently stable to allow long-term storage and distribution at ambient temperature, providing proof of principle of the feasibility of producing liquid food reference materials for the detection of nanoparticles. The spiked soups were characterized for particle diameter by EM and FFF-ICPMS (one material only), as well as for the total silica content. Although questions regarding the trueness of the results from EM and FFF-ICPMS procedures remain, the data obtained indicate that even assigning values should eventually be feasible. The materials can therefore be regarded as the first step towards certified reference materials for silica nanoparticles in a food matrix.

Keywords:Engineered nanoparticles, Colloidal silica, Reference material production, NotOAChecked
Subjects:D Veterinary Sciences, Agriculture and related subjects > D610 Food Science
F Physical Sciences > F110 Applied Chemistry
F Physical Sciences > F180 Analytical Chemistry
Divisions:College of Science > National Centre for Food Manufacturing
ID Code:16401
Deposited On:14 Jan 2015 16:04

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