Mosimann, U. P. and Mather, G. and Wesnes, K. A. and O'Brien, J. T. and Burn, D. J. and McKeith, I. G. (2004) Visual perception in Parkinson disease dementia and dementia with Lewy bodies. Neurology, 63 (11). pp. 2091-2096. ISSN 0028-3878
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Objective: To quantify visual discrimination, space-motion, and object-form perception in patients with Parkinson disease dementia (PDD), dementia with Lewy bodies (DLB), and Alzheimer disease (AD). Methods: The authors used a cross-sectional study to compare three demented groups matched for overall dementia severity (PDD: n = 24; DLB: n = 20; AD: n = 23) and two age-, sex-, and education-matched control groups (PD: n = 24, normal controls NC: n = 25). Results: Visual perception was globally more impaired in PDD than in nondemented controls (NC, PD), but was not different from DLB. Compared to AD, PDD patients tended to perform worse in all perceptual scores. Visual perception of patients with PDD/DLB and visual hallucinations was significantly worse than in patients without hallucinations. Conclusions: Parkinson disease dementia (PDD) is associated with profound visuoperceptual impairments similar to dementia with Lewy bodies (DLB) but different from Alzheimer disease. These findings are consistent with previous neuroimaging studies reporting hypoactivity in cortical areas involved in visual processing in PDD and DLB.
|Keywords:||aged, Alzheimer disease, article, comparative study, controlled study, dementia, depth perception, disease severity, education, female, human, Lewy body, major clinical study, male, motion, movement perception, Parkinson disease, pattern recognition, priority journal, scoring system, vision, visual discrimination, visual hallucination, Activities of Daily Living, Aged, 80 and over, Cognition, Cohort Studies, Discrimination (Psychology), Extrapyramidal Tracts, Form Perception, Hallucinations, Humans, Lewy Body Disease, Motion Perception, Perceptual Disorders, Psychomotor Performance, Reflex, Abnormal, Severity of Illness Index, Space Perception, Vision Tests, Visual Perception|
|Subjects:||B Subjects allied to Medicine > B140 Neuroscience|
C Biological Sciences > C860 Neuropsychology
|Divisions:||College of Social Science > School of Psychology|
|Deposited By:||George Mather|
|Deposited On:||04 Dec 2014 15:39|
|Last Modified:||04 Dec 2014 15:39|
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