Nutritional immunology: a multi-dimensional approach

Ponton, Fleur and Wilson, Kenneth and Cotter, Sheena C. and Raubenheimer, David and Simpson, Stephen J. (2011) Nutritional immunology: a multi-dimensional approach. PLoS Pathogens, 7 (12). e1002223. ISSN 1553-7366

Full content URL: http://dx.doi.org/10.1371/journal.ppat.1002223

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Abstract

Nutrition is critical to immune defence and resistance to pathogens, with consequences that affect the health, welfare and reproductive success of individual organisms [1,2], and also has profound ecological and evolutionary implications [3,4,5]. In humans, under-nutrition, notably of protein, is a major contributor to morbidity and mortality due to infectious diseases, particularly in the developing world [1]. Likewise, over-nutrition and its associated metabolic disorders may impair immune function, disrupt the relationship with symbiotic and commensal microbiota, and increase susceptibility to infectious disease [6]. Despite the undoubted importance of nutrition to immune defence, the challenge remains to capture the complexity of this relationship. There are three main aspects to this complexity: (i) nutrition is a complex multi-dimensional problem for hosts, pathogens and commensals; (ii) host immunity is a complex, multi-dimensional trait, and (iii) nutrition and immunity interact via multiple direct and indirect pathways, including involvement of the host’s microbiota.

Keywords:caloric restriction, self medication, nutritional ecology, geometric framework
Subjects:C Biological Sciences > C550 Immunology
C Biological Sciences > C360 Pest Science
C Biological Sciences > C111 Parasitology
C Biological Sciences > C182 Evolution
C Biological Sciences > C340 Entomology
C Biological Sciences > C150 Environmental Biology
C Biological Sciences > C180 Ecology
C Biological Sciences > C120 Behavioural Biology
C Biological Sciences > C300 Zoology
C Biological Sciences > C110 Applied Biology
C Biological Sciences > C100 Biology
Divisions:College of Science > School of Life Sciences
ID Code:16024
Deposited On:16 Nov 2014 21:10

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