Potential roles of eosinophils in cancer therapy: epidemiological studies, experimental models, and clinical pathology

Cao, Chao and Gu, Yangjun and Zhu, Chen and Palmai-Pallag, Timea and Lan, Fen and Chen, Zhihua and Li, Wen and Shen, Huahao and Ying, Songmin (2014) Potential roles of eosinophils in cancer therapy: epidemiological studies, experimental models, and clinical pathology. Recent Patents on Anti-Cancer Drug Discovery, 9 (2). pp. 241-248. ISSN 1574-8928

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Item Type:Article
Item Status:Live Archive

Abstract

Eosinophils play important roles in allergic diseases as well as during helminth infection. As multifunctional leukocytes, eosinophils have also been indicated in anti-cancer immunity. Published studies have suggested an association between allergic conditions and a trend of decreased risk in numerous malignances. Moreover, eosinophil infiltration in tumor tissue is considered an independent prognostic factor. Eosinophils are often recruited to tumor sites, where eosinophil granule proteins and cytokines are released upon activation, which in turn damage and kill tumor cells. In the last decade, a number of patents based on potential cancer therapy using eosinophilic cytokines have been awarded. In this article, we review the current findings on epidemiology, experimental models, clinical pathology, and molecular mechanisms involved in the response of eosinophils towards cancer. Moreover, we discuss promising targeted therapies with eosinophilic cytokines as a novel perspective to combat cancer.

Keywords:Allergy, eosinophils, IgE, interleukin-5, tumor-associated tissue eosinophilia, tumor immunology., NotOAChecked
Subjects:C Biological Sciences > C550 Immunology
Divisions:College of Science > School of Life Sciences
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ID Code:15998
Deposited On:13 Nov 2014 15:44

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