Costs of resistance: genetic correlations and potential trade-offs in an insect immune system

Cotter, S. C. and Kruuk, L. E. B. and Wilson, K. and UNSPECIFIED (2004) Costs of resistance: genetic correlations and potential trade-offs in an insect immune system. Journal of Evolutionary Biology, 17 (2). pp. 421-429. ISSN 1010-061X

Full content URL: http://dx.doi.org/10.1046/j.1420-9101.2003.00655.x

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Abstract

Theory predicts that natural selection will erode additive genetic variation in fitness-related traits. However, numerous studies have found considerable heritable variation in traits related to immune function, which should be closely linked to fitness. This could be due to trade-offs maintaining variation in these traits. We used the Egyptian cotton leafworm, Spodoptera littoralis, as a model system to examine the quantitative genetics of insect immune function. We estimated the heritabilities of several different measures of innate immunity and the genetic correlations between these immune traits and a number of life history traits. Our results provide the first evidence for a potential genetic trade-off within the insect immune system, with antibacterial activity (lysozyme-like) exhibiting a significant negative genetic correlation
with haemocyte density, which itself is positively genetically correlated with both haemolymph phenoloxidase activity and cuticular melanization. We speculate on a potential trade-off between defence against parasites and predators, mediated by larval colour, and its role in maintaining genetic variation in traits under natural selection.

Additional Information:Article first published online: 23 DEC 2003
Keywords:density-dependent prophylaxis, innate immunity, maternal effects, spodoptera littoralis, oaopen
Subjects:C Biological Sciences > C550 Immunology
C Biological Sciences > C360 Pest Science
C Biological Sciences > C111 Parasitology
C Biological Sciences > C182 Evolution
C Biological Sciences > C150 Environmental Biology
C Biological Sciences > C340 Entomology
C Biological Sciences > C120 Behavioural Biology
C Biological Sciences > C180 Ecology
C Biological Sciences > C300 Zoology
C Biological Sciences > C100 Biology
Divisions:College of Science > School of Life Sciences
ID Code:15963
Deposited On:11 Nov 2014 12:46

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