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Inflammation-induced DNA damage and damage-induced inflammation: a vicious cycle

Palmai-Pallag, Timea and Bachrati, Csanad (2014) Inflammation-induced DNA damage and damage-induced inflammation: a vicious cycle. Microbes and Infection, 16 (10). pp. 822-832. ISSN 1286-4579

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Inflammation-induced DNA damage and damage-induced inflammation: A vicious cycle
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Abstract

Inflammation is the ultimate response to the constant challenges of the immune system by microbes, irritants or injury. The inflammatory cascade initiates with the recognition of microorganism-derived pathogen associated molecular patterns (PAMPs) and host cell-derived damage associated molecular patterns (DAMPs) by the pattern recognition receptors (PRRs). DNA as a molecular PAMP or DAMP is sensed directly or via specific binding proteins to instigate pro-inflammatory response. Some of these DNA binding proteins also participate in canonical DNA repair pathways and recognise damaged DNA to initiate DNA damage response. In this review we aim to capture the essence of the complex interplay between DNA damage response and the pro-inflammatory signalling through representative examples.

Additional Information:Special issue: Intracellular stress and chronic inflammation
Keywords:DNA damage response, Inflammation, Oxidative DNA damage, Reactive oxygen species, Cell-free DNA, NotOAChecked
Subjects:C Biological Sciences > C130 Cell Biology
C Biological Sciences > C700 Molecular Biology, Biophysics and Biochemistry
Divisions:College of Science > School of Life Sciences
ID Code:15955
Deposited On:08 Nov 2014 18:44

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