Salivary cortisol response to awakening in chronic fatigue syndrome

Roberts, Amanda D. L. and Wessley, Simon and Chalder, Trudie and Papadopoulos, Andrew and Cleare, Anthony. J. (2004) Salivary cortisol response to awakening in chronic fatigue syndrome. The British Journal of Psychiatry, 184 (2). pp. 136-141. ISSN 0007-1250

Full content URL: http://dx.doi.org/10.1192/bjp.184.2.136

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Abstract

Background: There is accumulating evidence of hypothalamic-pituitary-adrenal (HPA) axis disturbances in chronic fatigue syndrome (CFS). The salivary cortisol response to awakening hasbeen described recentlyas a non-invasive test of the capacityof the HP Aaxis to respond to stress. The results of this test correlate closely with those of more invasive
dynamic tests reported in the literature; furthermore, i tcan be undertaken in a naturalistic setting.
Aims: To assess the HPA axis using the salivary cortisol response to awakening in CFS.
Method: We measured salivary cortisol upon awakening and 10, 20, 30 and 60 min afterwards in 56 patients with CFS and 35 healthy volunteers.
Results: Patients had a lower cortisol response to awakening, measured by the area under the curve.
Conclusions: This naturalistic test of the HPA axis response to stress showed impaired HPA axis function in CFS.

Keywords:Chronic fatigue syndrome, HPA Axis, Salivary cortisol response
Subjects:A Medicine and Dentistry > A300 Clinical Medicine
C Biological Sciences > C841 Health Psychology
Divisions:College of Social Science > School of Psychology
ID Code:15814
Deposited On:26 Oct 2014 20:57

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