Mind the gap: connexins and cell–cell communication in the diabetic kidney

Hills, Claire E. and Price, Gareth W. and Squires, Paul E. (2015) Mind the gap: connexins and cell–cell communication in the diabetic kidney. Diabetologia, 58 (2). pp. 233-241. ISSN 0012-186X

Documents
__ddat01_staffhome_bjones_RDS_Desktop_Diabetologia Review.pdf
[img]
[Download]
__ddat01_staffhome_bjones_RDS_Desktop_Diabetologia Review.docx

Request a copy
10 1007_s00125-014-3427-1-2.pdf

Request a copy
[img]
Preview
PDF
__ddat01_staffhome_bjones_RDS_Desktop_Diabetologia Review.pdf - Whole Document
Available under License Creative Commons Attribution.

223kB
[img] Microsoft Word
__ddat01_staffhome_bjones_RDS_Desktop_Diabetologia Review.docx - Whole Document
Restricted to Repository staff only
Available under License Creative Commons Attribution.

101kB
[img] PDF
10 1007_s00125-014-3427-1-2.pdf - Whole Document
Restricted to Repository staff only

993kB
Item Type:Article
Item Status:Live Archive

Abstract

Connexins, assembled as a hexameric connexon, form a transmembrane hemichannel that provides a conduit for paracrine signalling of small molecules and ions to regulate the activity and function of adjacent cells. When hemichannels align and associate with similar channels on opposing cells, they form a continuous aqueous pore or gap junction, allowing the direct transmission of metabolic and electrical signals between coupled cells. Regulation of gap junction synthesis and channel activity is critical for cell function, and a number of diseases can be attributed to changes in the expression/function of these important proteins. Diabetic nephropathy is associated with several complex metabolic and inflammatory responses characterised by defects at the molecular, cellular and tissue level. In both type 1 and type 2 diabetes, glycaemic injury of the kidney is the leading cause of end-stage renal failure, a consequence of multiple aetiologies, including increased deposition of extracellular matrix, glomerular hyperfiltration, albuminuria and tubulointerstitial fibrosis. In diabetic nephropathy, loss of connexin mediated cell–cell communication within the nephron may represent an early sign of disease; however, our current knowledge of the role of connexins in the diabetic kidney is sparse. This review highlights recent evidence demonstrating that maintenance of connexin-mediated cell–cell communication could benefit region-specific renal function in diabetic nephropathy and suggests that these proteins should be viewed as a tantalising novel target for therapeutic intervention.

Keywords:Diabetes, JCNotOpen
Subjects:B Subjects allied to Medicine > B990 Subjects Allied to Medicine not elsewhere classified
C Biological Sciences > C700 Molecular Biology, Biophysics and Biochemistry
Divisions:College of Science > School of Life Sciences
Related URLs:
ID Code:15536
Deposited On:16 Oct 2014 17:17

Repository Staff Only: item control page