Design of chimaeric polymersomes

Fraaije, J. G. E. M. and Van Sluis, C. A. and Kros, A. and Zvelindovsky, Andrei and Sevink, G. J. A. (2005) Design of chimaeric polymersomes. Faraday Discussions, 128 . pp. 355-361. ISSN 1359-6640

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Design of chimaeric polymersomes

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Abstract

We discuss the development of hierarchical polymer particles, or variegated polymersome composites, in which at least two different components are phase separated within one polymersome chimaera. We briefly discuss the present status in experimental polymersome research, and then discuss a speculative design strategy, based on mesoscopic simulations with a dynamical variant of polymer self-consistent field theory (Mesodyn). The main conclusion is that the counter-intuitive co-assembly of demixing block copolymers is the key in controlling hierarchical structures on a mesoscopic scale. This is the classical paradox of a chimaera: the constituents live in the same scaffold, but apart. Block copolymers beyond a certain length will always split the assembly, and without further precautions, polymer based chimaerae are intrinsically unstable. To this end, we propose the application of a branched block copolymer as composite compatibilizer, glueing the separate domains together, and thereby stabilizing the chimaeric polymersome.

Additional Information:First published online 29 Oct 2004
Keywords:copolymer, polymer, article, chemical structure, molecular stability, particle size, phase separation, polymerization, process design, simulation, structure analysis, theoretical study
Subjects:F Physical Sciences > F162 Polymer Chemistry
Divisions:College of Science > School of Mathematics and Physics
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ID Code:14985
Deposited On:29 Sep 2014 11:12

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