14 C autoradiography with a novel wafer scale CMOS Active Pixel Sensor

Esposito, Michela and Anaxagoras, Thalis and Larner, J and Allinson, Nigel and Wells, K (2013) 14 C autoradiography with a novel wafer scale CMOS Active Pixel Sensor. Journal of Instrumentation, 8 (1). C01011. ISSN 1748-0221

Full content URL: http://dx.doi.org/10.1088/1748-0221/8/01/C01011

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Item Type:Article
Item Status:Live Archive

Abstract

14 C autoradiography is a well established technique for structural and metabolic analysis of cells and tissues. The most common detection medium for this application is film emulsion, which offers unbeatable spatial resolution due to its fine granularity but at the same time has some limiting drawbacks such as poor linearity and rapid saturation. In recent years several digital detectors have been developed, following the technological transition from analog to digital-based detection systems in the medical and biological field. Even so such digital systems have been greatly limited by the size of their active area (a few square centimeters), which have made them unsuitable for routine use in many biological applications where sample areas are typically ~ 10–100 cm 2 . The Multidimensional Integrated Intelligent Imaging (MI3-Plus) consortium has recently developed a new large area CMOS Active Pixel Sensor (12.8 cm × 13.1 cm). This detector, based on the use of two different pixel resolutions, is capable of providing simultaneously low noise and high dynamic range on a wafer scale. In this paper we will demonstrate the suitability of this detector for routine beta autoradiography in a comparative approach with widely used film emulsion.

Additional Information:Part of 14th International Workshop on Radiation Imaging Detectors (IWORID2012)
Keywords:14C autoradiography, beta autoradiography, CMOS APS
Subjects:F Physical Sciences > F311 Engineering Physics
F Physical Sciences > F310 Applied Physics
Divisions:College of Science > School of Engineering
ID Code:14598
Deposited On:01 Aug 2014 12:47

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