Non-Ca2+-homeostatic functions of the extracellular Ca2+-sensing receptor (CaR) in endocrine tissues

Squires, Paul E. (2000) Non-Ca2+-homeostatic functions of the extracellular Ca2+-sensing receptor (CaR) in endocrine tissues. Journal of Endocrinology, 165 (2). pp. 173-177. ISSN 0022-0795

Full content URL: http://joe.endocrinology-journals.org/content/165/...

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Item Type:Article
Item Status:Live Archive

Abstract

The extracellular Ca2+-sensing receptor (CaR) links changes in the concentration of extracellular Ca2+ to changes in cell function. For cells involved in the control of systemic Ca2+ concentration, this provides an efficient receptor-mediated mechanism to rapidly counteract slight fluctuations in the circulating concentration of Ca2+. However, all cells that express the CaR are not necessarily involved in Ca2+ homeostasis. The recent localisation of CaR expression on a variety of cell types more usually associated with non-Ca2+-homeostatic endocrine function may have serious repercussions for the interpretation of data in those systems which routinely culture cells under standard hypercalcaemic conditions. This short commentary considers the literature surrounding the identification of the CaR and the potential effects of its localisation on endocrine cells not directly involved in the control of systemic Ca2+ homeostasis.

Keywords:calcium ion, calcium sensing receptor, calcium, cell surface receptor, calcium homeostasis, cell function, cell type, cellular distribution, endocrine function, extracellular calcium, human, hypercalcemia, priority journal, review, animal, extracellular space, gastrin cell, metabolism, pancreas islet, parathyroid gland, Animals, Gastrin-Secreting Cells, Humans, Islets of Langerhans, Parathyroid Glands, Receptors, Calcium-Sensing, Receptors, Cell Surface
Subjects:C Biological Sciences > C990 Biological Sciences not elsewhere classified
Divisions:College of Science > School of Life Sciences
ID Code:14353
Deposited On:18 Jun 2014 14:44

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