The calcium-sensing receptor and insulin secretion: a role outside systemic control 15 years on

Hodgkin, M. N. and Hills, C. E. and Squires, P. E. (2008) The calcium-sensing receptor and insulin secretion: a role outside systemic control 15 years on. Journal of Endocrinology, 199 (1). pp. 1-4. ISSN 0022-0795

Full content URL: http://dx.doi.org/10.1677/JOE-08-0261

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Abstract

In the 15 years since the identification and characterisation of the extracellular calcium-sensing receptor (CaR), it has become increasingly apparent that this cationic binding receptor is found in many tissues, not associated with the control of plasma calcium. One of these tissues is the pancreatic islet where insulin secretion provides the basis of energy regulation. It seems inherently unlikely that the islet responds to alterations in systemic calcium and a more plausible and intriguing possibility is that the CaR mediates cell-to-cell communication through local increases in the concentration of extracellular Ca2+, co-released with insulin. This short article explores this possibility and suggests that this novel mechanism of cell communication, along with direct coupling via gap junctions and other local paracrine regulators helps explain why the glucose responsiveness of the intact islet is greater than the sum of the composite parts in isolation.

Additional Information:Accepted Preprint first posted online on 24 June 2008
Keywords:Diebetes, Insulin, Human islets
Subjects:B Subjects allied to Medicine > B100 Anatomy, Physiology and Pathology
Divisions:College of Science > School of Life Sciences
ID Code:14139
Deposited On:27 May 2014 15:13

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