SGK1 in the kidney: disrupted sodium transport in diabetes and beyond

Hills, Claire E. and Bland, Rosemary and Squires, Paul E. (2009) SGK1 in the kidney: disrupted sodium transport in diabetes and beyond. Asia-Pacific Journal of Endocrinology, 1 (1). pp. 27-34. ISSN 2041-7993

Full content URL: http://issuu.com/sanlucasmedical/docs/apjoe.1.1

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Abstract

Renal complications of diabetes can be severe; however, the mechanisms that underlie the development and progression of diabetic nephropathy are poorly understood. Recent evidence suggests that the serum and glucocorticoid induced kinase-1 (SGK1) may be key to this process. SGK1 expression and function are increased in models of diabetes and polymorphisms of the SGK1 gene are associated with type 2 diabetes mellitus. A key regulator of sodium transport within the renal epithelium of the distal nephron, SGK1 was originally isolated as a glucocorticoid-sensitive gene that regulated the epithelial sodium channel (ENaC; known also as the sodium channel, nonvoltage-gated 1, SCNN1). It is now apparent that SGK1 modulates sodium re-absorption by a number of sodium transporters/channels throughout the length of the nephron including; the Na+/H+ exchange isoform 3 (NHE3), the Na+Cl- co-transporter (NCC) and the Na+/K+-ATPase. In addition, SGK1 is regulated by a diverse range of factors including; insulin, glucose, intracellular calcium, transforming growth factor-beta1, flow rate and osmolality. This brief review examines the evidence supporting an involvement of SGK1 in diabetic nephropathy and discusses how dysregulated sodium transport may account for the development of secondary hypertension associated with the condition. Furthermore, the article examines how aberrant SGK1 expression and activity may be responsible for the cellular changes seen in the damaged nephron.

Keywords:Diabetic nephropathy, Glucose, Sodium transport, SGK, Hypertension, oaopen
Subjects:Library of Congress Subject Areas > Q Science > Q Science (General)
Divisions:College of Science > School of Life Sciences
ID Code:14085
Deposited On:12 Mar 2012 09:24

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