Proton-counting radiography for proton therapy: a proof of principle using CMOS APS technology

Poludniowski, Gavin and Allinson, Nigel and Anaxagoras, Thalis and Esposito, Michela and Green, Stuart and Manolopoulos, Spyros and Nieto-Camero, Jamie and Parker, David and Evans, Philip and Price, Tony (2014) Proton-counting radiography for proton therapy: a proof of principle using CMOS APS technology. Physics in Medicine and Biology, 59 (11). pp. 2569-2598. ISSN 1361-6560

Documents
proton_counting_radiography_revised.pdf
[img]
[Download]
13879 additional 2015-NMA.pdf

Request a copy
[img]
Preview
PDF
proton_counting_radiography_revised.pdf - Whole Document

2MB
[img] PDF
13879 additional 2015-NMA.pdf - Supplemental Material
Restricted to Repository staff only

35kB
Item Type:Article
Item Status:Live Archive

Abstract

Despite the early recognition of the potential of proton imaging to assist proton therapy (Cormack 1963 J. Appl. Phys. 34 2722), the modality is still removed from clinical practice, with various approaches in development. For proton-counting radiography applications such as computed tomography (CT), the water-equivalent-path-length that each proton has travelled through an imaged object must be inferred. Typically, scintillator-based technology has been used in various energy/range telescope designs. Here we propose a very different alternative of using radiation-hard CMOS active pixel sensor technology. The ability of such a sensor to resolve the passage of individual protons in a therapy beam has not been previously shown. Here, such capability is demonstrated using a 36 MeV cyclotron beam (University of Birmingham Cyclotron, Birmingham, UK) and a 200 MeV clinical radiotherapy beam (iThemba LABS, Cape Town, SA). The feasibility of tracking individual protons through multiple CMOS layers is also demonstrated using a two-layer stack of sensors. The chief advantages of this solution are the spatial discrimination of events intrinsic to pixelated sensors, combined with the potential provision of information on both the range and residual energy of a proton. The challenges in developing a practical system are discussed.

Keywords:Proton, CMOS imagers, Proton therapy, NotOAChecked
Subjects:F Physical Sciences > F350 Medical Physics
Divisions:College of Science > School of Computer Science
ID Code:13879
Deposited On:02 May 2014 13:11

Repository Staff Only: item control page