Neutral gadolinium(III) complexes of bulky octadentate dtpa derivatives as potential contrast agents for magnetic resonance imaging

Annie Bligh, S.W. and Chowdhury, Anwar H.M.S. and McPartlin, Mary and Scowen, Ian J. and Bulman, Robert A. (1995) Neutral gadolinium(III) complexes of bulky octadentate dtpa derivatives as potential contrast agents for magnetic resonance imaging. Polyhedron, 14 (4). pp. 567-569. ISSN 0277-5387

Full content URL: http://dx.doi.org/10.1016/0277-5387(94)00318-9

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Item Type:Article
Item Status:Live Archive

Abstract

A series of bulky and neutral gadolinium complexes of [bis(R-amide)dtpaH3] (where R = Pri,, Bui,, Bz and phenylethyl, L1--L4)) with potential application as contrast agents for magnetic resonance imaging has been prepared and characterized ; the relaxivity of these complexes is comparable to the contrast agent [Gd(dtpa)(H2OO)]; which is which is currently used in clinics; the X-ray structure analysis of the gadolinium(III) complex of L3 reveals a neutral nine-coordinate complex featuring a water molecule in the tricapped trigonal prismatic metal coordination sphere.

Keywords:MRI
Subjects:F Physical Sciences > F100 Chemistry
Divisions:College of Science > School of Chemistry
ID Code:13113
Deposited On:19 Mar 2014 19:50

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