Phytochemistry and preliminary biological evaluation of Cyathostemma argenteum, a Malaysian plant used traditionally for the treatment of breast cancer

Khamis, S. and Bibby, M. C. and Brown, J. E. and Cooper, P. A. and Scowen, I. and Wright, C. W. (2004) Phytochemistry and preliminary biological evaluation of Cyathostemma argenteum, a Malaysian plant used traditionally for the treatment of breast cancer. Phytotherapy Research, 18 (7). pp. 507-510. ISSN 0951-418X

Full content URL: http://dx.doi.org/10.1002/ptr.1318

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Item Type:Article
Item Status:Live Archive

Abstract

Bioassay guided fractionation of the roots of Cyathostemma argenteum using the brine shrimp resulted in the isolation of two uncommon flavanones, 2,5-dihydroxy-7-methoxyflavanone 1 and 2,5-dihydroxy-6,7-dimethoxyflavanone 2 while the stem bark yielded the related compounds 5-hydroxy-7-methoxyflavone 3 and 5-hydroxy-6,7-dimethoxyflavone 4. The alkaloids liriodenine 5 and discretamine 6 as well as benzyl benzoate 7 were isolated from the roots and 6 was also isolated from the stembark. In cytotoxicity tests using four human breast cancer cell lines, 1 and 2 were weakly toxic to MCF-7 cells (IC 50 = 19.6 and 19.0 μm, respectively) but showed little activity against MCF-7 cells resistant to doxorubicin or against two oestrogen receptor-deficient cell lines. Compound 5, but not 6 and 7, was moderately cytotoxic against all four cell lines. These results are discussed in the context of the traditional use of C. argenteum in the treatment of breast cancer. Copyright © 2004 John Wiley & Sons, Ltd.

Additional Information:Article first published online: 3 AUG 2004
Keywords:2,5 dihydroxy 6,7 dimethoxyflavone, 2,5 dihydroxy 7 methoxyflavone, 5 hydroxy 6,7 dimethoxyflavone, alkaloid, benzyl benzoate, discretamine, doxorubicin, estrogen receptor, flavone derivative, liriodenine, tectochrysin, unclassified drug, antineoplastic activity, Artemia, article, bioassay, breast cancer, brine shrimp lethality test, cancer cell culture, controlled study, Cyathostemma argenteum, cytotoxicity, drug activity, drug isolation, drug resistance, human, human cell, IC 50, lethality, Malaysia, phytochemistry, plant root, proton nuclear magnetic resonance, traditional medicine, Animals, Annonaceae, Antineoplastic Agents, Phytogenic, Breast Neoplasms, Cell Line, Tumor, Female, Humans, Inhibitory Concentration 50, Medicine, Traditional, Phytotherapy, Plant Extracts, Plant Oils, Plant Roots, Anostraca, Decapoda (Crustacea), Mink cell focus-forming virus
Subjects:C Biological Sciences > C110 Applied Biology
F Physical Sciences > F100 Chemistry
Divisions:College of Science > School of Chemistry
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ID Code:13052
Deposited On:04 Apr 2014 09:57

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