Noninvasive in situ identification and band assignments of some pharmaceutical excipients inside USP vials with FT-near-infrared spectroscopy

Ali, Hassan R. H. and Edwards, Howell G. M. and Scowen, Ian J. (2009) Noninvasive in situ identification and band assignments of some pharmaceutical excipients inside USP vials with FT-near-infrared spectroscopy. Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 72 (4). pp. 890-896. ISSN 1386-1425

Full content URL: http://dx.doi.org/10.1016/j.saa.2008.12.010

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Item Type:Article
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Abstract

For the manufacture of dosage forms all ingredients must be reliably identified. In this paper, the suitability of FT-NIR spectroscopy to identify potassium sorbate, sodium starch glycollate, calcium ascorbate, calcium carbonate, candelilla wax, maltosextrin, monohydrated and anhydrous lactose inside USP vials was investigated. Differentiation between the anhydrous and monohydrated forms of lactose was found to be possible by studying the regions of the near-infrared spectrum corresponding to the combination and first overtone stretching frequencies of water. The results show unequivocally the potential of FT-NIR spectroscopy for rapid, in situ and non-destructive identification of pharmaceutical excipients. © 2008 Elsevier B.V. All rights reserved.

Keywords:Calcium, Calcium alloys, Catalyst activity, Drug products, Hydrates, Hydration, Infrared devices, Near infrared spectroscopy, Potassium, Sodium, Spectroscopic analysis, Spectroscopy, Spectrum analysis, Sugars, Textiles, Anhydrous, Band assignments, Calcium carbonates, Dosage forms, Ft-nir spectroscopies, In situ, Lactose hydrate, Near-infrared spectrum, Non-destructive, Pharmaceutical excipients, Pharmaceuticals excipients, Potassium sorbate, Stretching frequencies, Infrared spectroscopy, drug, excipient, glass, article, chemistry, drug packaging, infrared spectroscopy, methodology, near infrared spectroscopy, Drug Packaging, Excipients, Glass, Pharmaceutical Preparations, Spectroscopy, Fourier Transform Infrared, Spectroscopy, Near-Infrared
Subjects:F Physical Sciences > F100 Chemistry
Divisions:College of Science > School of Chemistry
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ID Code:13040
Deposited On:19 Mar 2014 18:49

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