Identification of a new co-crystal of salicylic acid and benzamide of pharmaceutical relevance

Elbagerma, M. A. and Edwards, H. G. M. and Munshi, T. and Scowen, I. J. (2010) Identification of a new co-crystal of salicylic acid and benzamide of pharmaceutical relevance. Analytical and Bioanalytical Chemistry, 397 (1). pp. 137-146. ISSN 1618-2642

Full content URL: http://dx.doi.org/10.1007/s00216-009-3375-7

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Abstract

Raman spectroscopy, X-ray powder diffraction/X-ray crystallography and differential scanning calorimetry have been used to study the phenomenon of co-crystal formation in stoichiometric mixtures of salicylic acid with benzamide. Raman spectroscopy was particularly useful for the characterization of the products and was used to determine the nature of the interactions in the co-crystals. It was observed that little change in the vibrational modes associated with the phenyl groups of the respective reactants took place upon co-crystal formation, but changes in intensities of the vibrational modes associated with the amide and the carboxylic acid groups were observed upon co-crystal formation. Several new vibrational bands were identified in the co-crystal which were not manifested in the physical mixture of both components and could be used as diagnostic features of co-crystal formation. © 2009 Springer-Verlag.

Keywords:Benzamides, Co-crystals, DSC, Hydrogen bondings, Salicylic acids, Amides, Carboxylic acids, Crystals, Differential scanning calorimetry, Hydrogen bonds, Organic acids, Raman scattering, Raman spectroscopy, X ray crystallography, Cobalt, benzamide, benzamide derivative, salicylic acid, chemical structure, chemistry, conference paper, crystallization, Raman spectrometry, X ray crystallography, X ray diffraction, Benzamides, Calorimetry, Differential Scanning, Crystallography, X-Ray, Models, Molecular, Molecular Structure, Salicylic Acid, Spectrum Analysis, Raman, X-Ray Diffraction
Subjects:F Physical Sciences > F100 Chemistry
Divisions:College of Science > School of Chemistry
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ID Code:13033
Deposited On:19 Mar 2014 19:18

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