Murid herpesvirus-4 exploits dendritic cells to infect B cells

Gaspar, Miguel and May, Janet S. and Sukla, Soumi and Frederico, Bruno and Gill, Michael B. and Smith, Christopher M. and Belz, Gabrielle T. and Stevenson, Philip G. (2011) Murid herpesvirus-4 exploits dendritic cells to infect B cells. PLoS Pathogens, 7 (11). ISSN 1553-7366

Full content URL: http://www.plospathogens.org/article/info%3Adoi%2F...

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Abstract

Dendritic cells (DCs) play a central role in initiating immune responses. Some persistent viruses infect DCs and can disrupt their functions in vitro. However, these viruses remain strongly immunogenic in vivo. Thus what role DC infection plays in the pathogenesis of persistent infections is unclear. Here we show that a persistent, B cell-tropic gamma-herpesvirus, Murid Herpesvirus-4 (MuHV-4), infects DCs early after host entry, before it establishes a substantial infection of B cells. DC-specific virus marking by cre-lox recombination revealed that a significant fraction of the virus latent in B cells had passed through a DC, and a virus attenuated for replication in DCs was impaired in B cell colonization. In vitro MuHV-4 dramatically altered the DC cytoskeleton, suggesting that it manipulates DC migration and shape in order to spread. MuHV-4 therefore uses DCs to colonize B cells.

Additional Information:Journal listed in Directory of Open Access Journals (DOAJ)
Keywords:Dendritic cells, immune response, virus, Vaccine
Subjects:B Subjects allied to Medicine > B131 Cellular Pathology
C Biological Sciences > C130 Cell Biology
Divisions:College of Science > School of Life Sciences
ID Code:12909
Deposited On:08 Jan 2014 15:33

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