CMOS APS in pre-clinical science: next generation disruptive technology for multi-modality imaging

Esposito, M. and Bailey, A. and Newcombe, J. and Anaxagoras, T. and Allinson, N. M. and Wells, K. (2012) CMOS APS in pre-clinical science: next generation disruptive technology for multi-modality imaging. In: 2012 IEEE Nuclear Science Symposium and Medical Imaging Conference, 29 October - 3 November 2012, Anaheim, CA.

Full content URL: http://dx.doi.org/10.1109/NSSMIC.2012.6551442

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Item Type:Conference or Workshop contribution (Paper)
Item Status:Live Archive

Abstract

A new large area CMOS Active Pixel Sensor has been developed as single platform technology to be used across a range of ionizing and non-ionizing imaging applications in preclinical science, ranging from imaging of protein sequences to functional analysis of radio-labeled tissue sections.We present the first images of chemiluminescence detection in western blotting with a room temperature CMOS APS. Detection performance in western blotting have been compared with the gold standard detection medium, film emulsion, showing higher dynamic range and sensitivity with this new device. We also report on our first images of 125IEpibatidine autoradiography of brain sections using a novel large area CMOS APS. © 2012 IEEE.

Additional Information:Conference Code:98448
Keywords:Chemiluminescence detection, CMOS; Large area image sensors, Life science imaging applications, Pre-clinical imaging, Trapped Charge Emission, Semiconductor Devices, Charge Coupled, APS, Autoradiography, Chemiluminescence, CMOS integrated circuits, Emulsification, Nuclear physics, Radiography
Subjects:G Mathematical and Computer Sciences > G400 Computer Science
F Physical Sciences > F350 Medical Physics
B Subjects allied to Medicine > B800 Medical Technology
Divisions:College of Science > School of Computer Science
ID Code:11733
Deposited On:22 Jan 2014 10:23

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