Xanthones as inhibitors of microsomal lipid peroxidation and TNF-alpha induced ICAM-1 expression on human umbilical vein endothelial cells (HUVECs)

Madan, Babita and Singh, Ishwar and Kumar, Ajit and Prasad, Ashok K. and Raj, Hanumantharao G. and Parmar, Virinder S. and Ghosh, Balaram (2002) Xanthones as inhibitors of microsomal lipid peroxidation and TNF-alpha induced ICAM-1 expression on human umbilical vein endothelial cells (HUVECs). Bioorganic and Medicinal Chemistry, 10 (11). pp. 3431-3436. ISSN 0968-0896

Full content URL: http://dx.doi.org/10.1016/S0968-0896(02)00262-6

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Item Type:Article
Item Status:Live Archive

Abstract

Xanthones bearing different functionalities, namely 1-hydroxyxanthone (1), 3-hydroxyxanthone (2), 1,4-dihydroxyxanthone (3), 2,6-dihydroxyxanthone (4), 1,2-diacetoxyxanthone (5), 2,6-diacetoxyxanthone (6), 3-methoxyxanthone (7), 1,3,7-trimethoxyxanthone (8) and 1,5-dihydroxy-6-methoxyxanthone (9) were synthesised and examined for their effect on nicotinamide adenine dinucleotide phosphate (NADPH)-catalysed liver microsomal lipid peroxidation and on tumour necrosis factor-alpha (TNF-alpha) induced expression of intercellular adhesion moledule-1 (ICAM-1) on endothelial cells, with a view to establish structure-activity relationship. Hydroxy- and acetoxyxanthones showed potent inhibitory effects on NADPH-catalysed lipid peroxidation and TNF-a induced expression of ICAM-1 on endothelial cells. (C) 2002 Elsevier Science Ltd. All rights reserved.

Keywords:Xanthone
Subjects:B Subjects allied to Medicine > B200 Pharmacology, Toxicology and Pharmacy
Divisions:College of Science > School of Pharmacy
ID Code:11312
Deposited On:24 Jul 2013 07:54

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